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KMID : 0950020060320010117
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Journal of Health Science & Medical Technology
2006 Volume.32 No. 1 p.117 ~ p.121
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Effects of Dimethyl sulfoxide on formaldehyde and organic solvents-induced inhibition of cell growth
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Choi Dal-Woong
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Abstract
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Dimethyl sulfoxide has been shown to have toxicity interaction with many organic solvents. Dimethyl sulfoxide was shown to enhance toxicity of solvents, while some other studies demonstrated reduction of solvent toxicity by dimethyl sulfoxide. Form-aldehyde is a toxic and irritant indoor air pollutant found at relatively high concentrations in new house, schools and offices in developed countries. Exposure to formaldehyde elicits a variety of allergic signs and symptoms and irritates human cell. We are highly exposed to formaldehyde in living environment. The aim of the present study was to investigate the effect of dimethyl sulfoxide and formaldehyde or organic solvents on the cell growth. Cell growth was measured after 24h treatment with formaldehyde or organic solvents such as toluene, ethylbenzene, isopropyl alcohol, carbon tetrachloride, pyridine, glycerine. The cell growth was not inhibited after exposure of isopropyl alcohol(100 mM), pyridine(100 mM) or glycerine(100 mM). Treatment of formaldehyde(100 mM), toluene(100 mM), ethylbenzene(100 mM) and carbon tetrachloride(100 mM) strongly inhibited the cell growth. However, treatment of 10mM toluene, 10 mM ethylbenzene and 10mM carbon tetrachloride showed no effects on cell growth. The most potent inhibition of cell growth was observed after exposure to formaldehyde. Even 1 mM formaldehyde strongly inhibited cell growth. The cell growth was also measured after 24 h co-exposure of dimethyl sulfoxide and formaldehyde or organic solvents. Addition of dimethyl sulfoxide did not modify the cell proliferation pattern induced by organic solvents. Any antagonistic or additive effect of dimethyl sulfoxide was not observed. These results show that organic solvents induce inhibition of cell growth with different potency. These study can give valuable information about toxicity interaction of dimethyl sulfoxide and formaldehyde or organic solvents.
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KEYWORD
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Dimethyl sulfoxide, formaldehyde, organic solvents
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